A Mini Review on Antimicrobial Activities of Different Substituted Pyridazinone Derivatives
نویسنده
چکیده
Abstract: The effective methods have been developed for the preparation under mild conditions of novel pyridazine derivatives from the easily accessible starting materials. All the synthesized compounds were fully characterized. Various pyridazinone compounds were synthesized and tested for their antibacterial against various Gram positive and Gram negative bacterial strains such as Staphylococcus aureus, Bacillus cereus, B. subtilis, Staphylococcus epidermidis, Pseudomonas aeruginosa, Escherichia coli, Micrococcus luteus, S. flexneri and Klebsiella pneumonia and antifungal activities on some fungal species, namely Candida albicans, C. neoformans, Trichophyton rubrum, Aspergillus flavus, Aspergillus niger, G. zeae, F. oxysporum and C. mandshurica and Penicillium citrinum. The results indicated that the synthesized pyridazine compounds have mild to potent antibacterial and antifungalactivities with reference to their appropriate standard reference drugs.
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تاریخ انتشار 2017